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Updated: Aug 23, 2026
Anti-Nuclear Antibody Screening Using HEp-2 Cells
Published on: June 23, 2014
Antinucleolar antibody associated with lupus erythematosus in a dog
Abstract:
A nucleolar pattern of fluorescence was detected in an Antinuclear Antibody (ANA) test on serum of an 8-year-old Collie with Systemic Lupus Erythematosus (SLE). Skin disease characterized by a lymphoplasmacytic infiltrate and epidermal necrosis and a positive Coombs' test supported the diagnosis. The dog responded to immunosuppressive drugs and continues to do well on maintenance therapy.
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