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Updated: Aug 23, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Design of acid-base catalysis for the asymmetric direct Aldol reaction
Susumu Saito1, Hisashi Yamamoto
1Institute for Advanced Research & Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan.
Abstract:
Proper design of acid-base catalysis has been shown to be effective for achieving high reactivity and selectivity in the asymmetric direct aldol reaction during the development of diamine-Brønsted acid types of catalyst. In this study, two principal approaches have been implemented to create a new type of catalysis and high catalytic efficiency: one is the creation of a highly viable acidic function within acid-base catalysts; the other is the creation of rather complicated but more cooperatively arranged hydrogen-bond networks that would be expected to stabilize a transition state, thereby promoting new reactivity and selectivity.
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