Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Herpes simplex virus-based vectors.

Robin Lachmann1

  • 1Department of Medicine, University of Cambridge, Cambridge, UK. rhl20@cam.ac.uk

International Journal of Experimental Pathology
|August 18, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adults With Acid Sphingomyelinase Deficiency Have Sustained Improvements in Clinical Outcomes With up to 5 Years of Olipudase Alfa Enzyme Replacement Therapy: ASCEND Trial Final Results.

Journal of inherited metabolic disease·2026
Same author

Advances in Therapeutics-Enzyme Replacement Therapy: Long-Term Evaluation and New Approaches.

Journal of inherited metabolic disease·2026
Same author

Enzyme replacement therapy compared with best supportive care for the treatment of Pompe Disease: a systematic review and network meta-analysis.

Health technology assessment (Winchester, England)·2026
Same author

Cardiovascular Morbidity and Mortality in Fabry Disease.

Circulation. Genomic and precision medicine·2026
Same author

Correspondence on "Phenylalanine hydroxylase deficiency diagnosis and management: A 2023 evidence-based clinical guideline of the American College of Medical Genetics and Genomics (ACMG)" by Smith et al.

Genetics in medicine : official journal of the American College of Medical Genetics·2026
Same author

The cost-effectiveness of enzyme replacement therapies versus best supportive care for treating late onset Pompe disease in the UK NHS.

The European journal of health economics : HEPAC : health economics in prevention and care·2025
Same journal

Exosomal miR-221-3p derived from bone marrow mesenchymal stem cells alleviates endoplasmic reticulum stress-mediated apoptosis in nucleus pulposus cells via the Nrf2/HO-1 signalling pathway.

International journal of experimental pathology·2025
Same journal

Effect of pulmonary arterial hypertension on the morphology and antioxidant defence of the ventral prostate of sedentary and exercised rats.

International journal of experimental pathology·2025
Same journal

Correction to 'The Energy Density of Laser Light Differentially Modulates the Skin Morphological Reorganization in a Murine Model of Healing by Secondary Intention'.

International journal of experimental pathology·2025
Same journal

Roles of long non-coding RNAs in oesophageal cancer pathogenesis.

International journal of experimental pathology·2025
Same journal

Porcine respiratory disease complex induces pulmonary fibrosis related to the aberrant sphingolipid metabolism.

International journal of experimental pathology·2025
Same journal

Molecular epidemiology of Epstein-Barr virus in gastric cancer patients compared to healthy control group in Shiraz, Iran.

International journal of experimental pathology·2025
See all related articles

Herpes simplex virus (HSV)-based vectors are engineered for neuronal gene delivery. This review details methods to reduce HSV cytotoxicity and explores long-term transgene expression for potential clinical applications.

Area of Science:

  • Neuroscience
  • Virology
  • Gene Therapy

Background:

  • Herpes simplex virus (HSV) possesses natural neurotropism, making it suitable for neuronal gene delivery.
  • Existing HSV vectors include replication-defective viruses and amplicon vectors.
  • Cytotoxicity of wild-type HSV has been a challenge for vector development.

Purpose of the Study:

  • To review methods for abolishing HSV cytotoxicity in vector development.
  • To discuss progress in identifying promoter elements for sustained transgene expression from latent HSV genomes.
  • To explore potential clinical applications of HSV-based vectors.

Main Methods:

  • Review of literature on HSV vector development.
  • Analysis of strategies to eliminate viral cytotoxicity.

Related Experiment Videos

  • Examination of promoter elements for long-term gene expression.
  • Discussion of clinical potential.

    • Main Results:

    • Cytotoxicity of wild-type HSV can be abolished through gene deletion.
    • Progress has been made in defining promoter elements for long-term transgene expression.
    • HSV-based vectors show promise for various clinical applications.

    Conclusions:

    • HSV-based vectors offer a versatile platform for neuronal gene delivery.
    • Further research into promoter elements and vector optimization is ongoing.
    • HSV vectors hold significant potential for future clinical therapies.