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Brazilian Sepsis Epidemiological Study (BASES study).

Eliézer Silva1, Marcelo de Almeida Pedro, Ana Cristina Beltrami Sogayar

  • 1Intensive Care Unit, Hospital Israelita Albert Einstein, São Paulo, Brazil. eliezer@einstein.br <eliezer@einstein.br>

Critical Care (London, England)
|August 18, 2004
PubMed
Summary

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This summary is machine-generated.

Sepsis is a significant public health issue in Brazilian intensive care units (ICUs), with high incidence rates and mortality. Sepsis severity strongly correlates with patient outcomes.

Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Epidemiology

Background:

  • Limited data exists on sepsis incidence and outcomes in Latin American intensive care units (ICUs), particularly in Brazil.
  • This study aimed to determine the incidence density and outcomes of sepsis in Brazilian ICUs.

Purpose of the Study:

  • To investigate the incidence density of sepsis, severe sepsis, and septic shock in Brazilian ICUs.
  • To assess the association between Consensus Conference criteria and patient outcomes.
  • To identify the primary sources of infection in ICU patients.

Main Methods:

  • A multicenter observational cohort study was conducted in five mixed ICUs across two regions in Brazil.
  • 1383 adult patients were prospectively followed from admission until discharge, 28-day survival, or death.

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  • Data collected included demographics, diagnoses, APACHE II scores, underlying diseases, SIRS criteria, sepsis definitions, and SOFA scores.

    • Main Results:

    • The overall 28-day mortality rate was 21.8%.
    • Incidence densities per 1000 patient-days were: sepsis (61.4), severe sepsis (35.6), and septic shock (30.0).
    • Mortality rates increased with sepsis severity, from 24.3% for SIRS to 52.2% for septic shock. Lung/respiratory tract was the main infection source.

    Conclusions:

    • Sepsis represents a major public health problem in Brazilian ICUs, with an estimated incidence density of 57 per 1000 patient-days.
    • A strong association was observed between ACCP/SCCM sepsis categories and mortality rates.
    • Findings highlight the need for improved sepsis management strategies in Brazil.