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Related Experiment Videos

A rhythmic Ror.

Patrick Emery1, Steven M Reppert

  • 1Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA.

Neuron
|August 18, 2004
PubMed
Summary
This summary is machine-generated.

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The mammalian circadian clock relies on two feedback loops. New findings reveal that Rora, a transactivator, works with Rev-erb alpha to regulate Bmal1 transcription, defining a key second loop.

Area of Science:

  • Chronobiology
  • Molecular Biology
  • Genetics

Background:

  • Mammalian circadian clocks utilize interlocking transcriptional feedback loops.
  • Rev-erb alpha was previously considered the main regulator of Bmal1 transcription via repression.

Purpose of the Study:

  • To elucidate the precise molecular mechanisms driving the circadian rhythm of Bmal1 transcription.
  • To identify additional factors involved in the mammalian circadian clock's feedback loops.

Main Methods:

  • The study by Sato et al. investigated the roles of Rora and Rev-erb alpha in regulating Bmal1 transcription.
  • Analysis focused on their coordinated activities on the Bmal1 promoter element.

Main Results:

  • Rora, a transactivator, acts coordinately with the repressor Rev-erb alpha.

Related Experiment Videos

  • Their competing activities on the same promoter element are crucial for driving the rhythm in Bmal1 transcription.

    • Conclusions:

    • This study defines the second transcriptional feedback loop in the mammalian circadian clock.
    • The interplay between Rora and Rev-erb alpha is essential for circadian rhythmicity.