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Intrabodies as therapeutic agents

Roland E Kontermann1

  • 1Vectron therapeutics AG, Rudolf-Breitscheid-Str. 24, 35037 Marburg, Germany. kontermann@vectron-ag.com

Methods (San Diego, Calif.)
|August 18, 2004
PubMed

In the past decade, a large number of intracellular antibodies (intrabodies) have been developed for potential use as therapeutic agents. As antibodies can be generated against virtually any target antigen, the applications of intrabodies span a wide range including tumour therapy, infectious diseases, transplantation, and other diseases associated with protein overexpression or mutagenesis. This article summarises the development of intrabodies and their applications as therapeutic agents.

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