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Related Experiment Videos

Impaired conditioned taste aversion learning in APP transgenic mice.

Christopher Janus1, Hans Welzl, Amanda Hanna

  • 1Centre for Research in Neurodegenerative Diseases, University of Toronto, 6 Queen's Park Crescent West, Toronto, Ont., Canada M5S 3H2. janus@psych.utoronto.ca

Neurobiology of Aging
|August 18, 2004
PubMed
Summary

Transgenic mice modeling Alzheimer's disease (AD) exhibit impaired implicit memory. The conditioned taste aversion (CTA) task revealed deficits in associative learning in these APP mice, suggesting a broader cognitive impact of the disease.

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Area of Science:

  • Neuroscience
  • Genetics
  • Pharmacology

Background:

  • Alzheimer's disease (AD) cognitive deficits extend beyond explicit memory, impacting implicit memory systems.
  • Transgenic mouse models are crucial for studying AD pathogenesis and cognitive dysfunction.
  • Previous studies focused on explicit spatial memory deficits in AD models.

Purpose of the Study:

  • To evaluate implicit associative learning in TgCRND8 transgenic mice modeling Alzheimer's disease.
  • To assess the utility of the conditioned taste aversion (CTA) paradigm in detecting implicit memory impairments in AD models.

Main Methods:

  • Utilized the conditioned taste aversion (CTA) paradigm, a form of Pavlovian classical conditioning.
  • TgCRND8 transgenic mice and non-transgenic littermates were exposed to a novel taste paired with nausea induction.

Related Experiment Videos

  • Assessed learning by measuring aversion to the novel taste over repeated trials.

    • Main Results:

    • TgCRND8 mice demonstrated significantly weaker aversion to the novel taste compared to non-transgenic controls.
    • TgCRND8 mice increased consumption of the conditioned taste in repeated tests, indicating impaired associative learning.
    • Control experiments confirmed comparable taste sensitivities between TgCRND8 and non-Tg mice.

    Conclusions:

    • TgCRND8 mice exhibit significant impairments in implicit associative learning, in addition to previously documented explicit memory deficits.
    • The CTA paradigm is a sensitive tool for evaluating implicit learning deficits in APP transgenic mouse models of AD.
    • Findings suggest that AD pathology affects multiple memory systems, including implicit associative learning.