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Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation
Published on: June 26, 2013
Protein synthesis, PKA, and MAP kinase are differentially involved in short- and long-term memory in rats
João Quevedo1, Mônica R M Vianna, Márcio Rodrigo Martins
1Laboratório de Neurotoxicologia, Universidade do Extremo Sul Catarinense, Av. Universitaria 1105, Criciúma 88806-000, SC, Brazil. quevedo1@terra.com.br
Abstract:
We studied the involvement of hippocampal protein synthesis-, PKA-, and MAP kinase-dependent processes in short- (STM) and long-term memory (LTM) for inhibitory avoidance task. Fifteen minutes before or immediately after training rats received intrahippocampal infusions of vehicle, the protein synthesis inhibitor anisomycin, the PKA inhibitor Rp-cAMPs or the MAPKK inhibitor PD098059. The results show that STM recruits PKA and MAPK, whereas, LTM depends on PKA activity and protein synthesis during the early post-training period.
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