Effects of single pulse TMS on spatio-temporal integration in sequential isochronus movements

This study was designed to investigate the effect of single pulse transcranial magnetic stimulation (TMS) on the isochronic performance of sequential movements which were recorded using a digitising pad. Magnetic stimulation was applied through an 8-shaped magnetic coil over primary motor and premotor cortex at a specific time point while executing the first of a three movement sequence. TMS applied to the premotor cortex showed an alteration effect on the first movement while stimulation of the primary motor cortex influenced the second movement in the sequence. Results suggest that the premotor cortex is involved in online monitoring and controlling of spatio-temporal features of trajectories while the motor cortex contributes to the execution of movements. Isochrony is maintained to a high degree under TMS which has been found in other studies to delay reaction times. The results show that although TMS has a significant influence on motor performance, isochrony is a robust component of motor programs, not readily to be disturbed.