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Modulation of poly(ADP-ribosylation) in apoptotic cells
A Ivana Scovassi1, Marc Diederich
1Istituto di Genetica Molecolare CNR, Via Abbiategrasso 207, I-27100 Pavia, Italy. scovassi@igm.cn.it
Biochemical Pharmacology
|August 18, 2004
Abstract:
Poly(ADP-ribosylation) is a post-translational modification of proteins playing a crucial role in DNA repair, replication, transcription and cell death. In this paper, the main features of this process have been reviewed, focusing on the best known poly(ADP-ribose) polymerizing enzyme, PARP-1, a DNA nick-sensor protein that uses beta-NAD+ to form polymers of ADP-ribose. The modulation of poly(ADP-ribosylation) during apoptosis and the possible effects of its inhibition on cell metabolism are discussed.