Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adhesion molecules on human tonsil dendritic cells.

T C Prickett1, J L McKenzie, D N Hart

  • 1Department of Haematology, Christchurch Hospital, New Zealand.

Transplantation
|February 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immune development and performance characteristics of Romney sheep selected for either resistance or resilience to gastrointestinal nematodes.

Veterinary parasitology·2018
Same author

Intrinsic reproductive isolating mechanisms in the maintenance of a hybrid zone between ecologically divergent subspecies.

Journal of evolutionary biology·2017
Same author

Genetic identification of istiophorid larvae from the Gulf of Mexico based on the analysis of mitochondrial DNA control region sequences.

Journal of fish biology·2016
Same author

Incidence of cutaneous squamous cell carcinoma in a New Zealand population of chronic lymphocytic leukaemia patients.

Internal medicine journal·2016
Same author

Transcription of the apicoplast genome.

Molecular and biochemical parasitology·2016
Same author

Chronic lymphocytic leukaemia cells become both activated and immunosuppressive following interaction with CD3 and CD28 stimulated PBMC.

Leukemia research·2014
Same journal

Filtered or Fried? Rethinking Intraoperative Cell Salvage in Liver Transplantation.

Transplantation·2026
Same journal

Simultaneous Liver-kidney Versus Liver Transplantation Categorized by Pretransplant eGFR: Impact of the 2017 OPTN Policy.

Transplantation·2026
Same journal

Preformed Anti-DQ Alpha Donor-specific Antibodies and the Risk of Antibody-mediated Rejection After Kidney Transplantation.

Transplantation·2026
Same journal

People in Transplantation: Professor Nadey Hakim, MD, PhD, FRCS, FRCSGlas (Hon), FACS, President-Elect of The Transplantation Society.

Transplantation·2026
Same journal

IL-1 Receptor Blockade Modulates Inflammation During Sequential Perfusion in Ex Vivo Porcine Kidneys.

Transplantation·2026
Same journal

Regulatory T Cells Allosensitized Under the Blockade of CD80/CD86-CD28 Costimulation Prolonged Islet Allograft Survival.

Transplantation·2026
See all related articles

Dendritic cells (DCs) use adhesion molecules like LFA-1 and LFA-3 to interact with T cells, crucial for immune responses. Blocking these molecules significantly impacts DC-T cell clustering and activation, revealing key interactions in adaptive immunity.

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • Dendritic cells (DCs) are key antigen-presenting cells initiating T cell responses.
  • DC-T cell activation involves cell-cell contact mediated by adhesion molecules.

Purpose of the Study:

  • To investigate the role of adhesion molecules in DC-T cell interactions.
  • To identify specific adhesion molecules involved in DC-mediated T cell activation.

Main Methods:

  • Utilized monoclonal antibodies to probe adhesion molecule expression on DCs.
  • Assessed the impact of antibody blockade on DC-stimulated allogeneic T cell responses (MLR).
  • Analyzed DC-T cell cluster stability and identified ligand-receptor interactions.

Main Results:

Related Experiment Videos

  • DCs express LFA-1, ICAM-1, LFA-3, and Hermes antigen.
  • Antibodies against LFA-1 and LFA-3 significantly inhibited MLR responses.
  • Anti-ICAM-1 antibodies showed limited inhibition, suggesting complex interactions.
  • Identified at least three independent adhesion interactions: LFA-1-ICAM-1, ICAM-1-LFA-1, and LFA-3-CD2.

Conclusions:

  • LFA-1 and LFA-3 play critical roles in DC-T cell adhesion and activation.
  • ICAM-2 may also contribute to DC-T cell interactions.
  • Understanding these adhesion dynamics is vital for modulating immune responses.