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Mild cognitive impairment: a cross-national comparison
E Arnáiz1, O Almkvist, R J Ivnik
1Karolinska Institutet, Neurotec Department, Huddinge University Hospital, Stockholm, Sweden.
Journal of Neurology, Neurosurgery, and Psychiatry
|August 18, 2004
Summary
The number of cognitive impairments predicts Alzheimer's disease progression. Learning and retention tests are key indicators for identifying individuals at risk of developing Alzheimer's disease (AD).
Area of Science:
- Neuroscience
- Gerontology
Background:
- Mild cognitive impairment (MCI) criteria vary, impacting comparability across studies.
- Understanding MCI progression is crucial for early Alzheimer's disease (AD) intervention.
Purpose of the Study:
- Compare MCI diagnostic criteria between Mayo Clinic (USA) and Karolinska Institutet (Sweden).
- Identify predictors for conversion from MCI to Alzheimer's disease (AD).
Main Methods:
- Standardized neuropsychological tests assessed cognitive performance in MCI patients.
- Cox proportional hazard and logistic regression models analyzed predictors of AD conversion.
Main Results:
- The number of impaired cognitive domains significantly predicted time to AD diagnosis.
- Cognitive assessment results remained significant predictors regardless of institution.
- Tests measuring learning and retention were identified as key predictors for AD development.
Conclusions:
- Variability in MCI samples may stem from population and methodological differences.
- Baseline cognitive impairment predicts MCI to AD progression.
- Learning and retention assessments are optimal for predicting AD progression.