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Updated: Jul 21, 2026

Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis
Published on: September 11, 2019
Animal models of cancer and HIV
Mahesh Patel1, Harris Goldstein
1Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Purpose Of Review:
The purpose of this paper is to review current animal models that may be useful for studying cancer associated with human immunodeficiency virus infection.
Recent Findings:
Several animal models, primarily using mice and monkeys, have been developed that recapitulate aspects of the pathology of various malignancies in human acquired immune deficiency syndrome. Studies reviewed here help to elucidate the biology of Kaposi sarcomagenesis and non-Hodgkin lymphomagenesis. Improved understanding through current and future models will better enable clinicians to manage and treat these malignancies.
Summary:
A number of potential useful models exist that may facilitate improved understanding of the pathogenesis and treatment of cancers associated with human immunodeficiency virus infection.
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