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Hepcidin in iron metabolism.

Tomas Ganz1

  • 1Departments of Medicine and Pathology, David Geffen School of Medicine University of California, Los Angeles, California 90095-1690, USA. tganz@mednet.ucla.edu

Current Opinion in Hematology
|August 18, 2004
PubMed
Summary

Hepcidin, a key regulator of iron metabolism, influences iron absorption, transport, and release. Research into this hepatic peptide is advancing understanding of iron homeostasis and potential treatments for iron disorders.

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Area of Science:

  • Biochemistry
  • Genetics
  • Cell Biology

Background:

  • Hepcidin is a hepatic peptide regulating iron absorption and transport.
  • It influences iron release from stores and macrophages.
  • Hepcidin connects iron metabolism to innate immunity, mediating inflammation-induced hypoferremia.

Purpose of the Study:

  • To elucidate the essential role of hepcidin in iron metabolism.
  • To understand hepcidin's regulation of intestinal iron absorption and maternal-fetal iron transport.
  • To explore hepcidin's role in iron release and its connection to innate immunity.

Main Methods:

  • Mouse and human genetics.
  • Biochemistry.
  • Cell biology.

Main Results:

  • The essential role of hepcidin in iron metabolism is being elucidated.
  • Hepcidin's function in regulating iron absorption, transport, and release is being clarified.
  • Its role as a mediator of hypoferremia of inflammation is being established.

Conclusions:

  • Studies of hepcidin are leading to a fundamental understanding of iron homeostasis.
  • Research points to potential treatments for hemochromatosis.
  • Potential treatments for anemia of inflammation (anemia of chronic disease) are being identified.

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