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Updated: Aug 23, 2026

Burn Injury-Induced Pain and Depression-Like Behavior in Mice
Published on: September 29, 2021
Common pathways of depression and pain
1Department of Psychiatry, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, Ohio 44106-5080, USA. pedro.delgado@case.edu
Abstract:
Depressive disorders are chronic conditions that produce both emotional and physical symptoms. Increasing evidence suggests that in some patients with depressive disorders a neurodegenerative process may occur, highlighting the importance of early and aggressive intervention. Serotonin (5-HT) and norepinephrine (NE) neurotransmitter systems influence neuroplasticity in the brain, and both are involved in mediating the therapeutic effects of most currently available antidepressants. Some dual-action antidepressants have been shown to be effective in managing the pain symptoms associated with depression. These agents may have advantages over others by treating a wider array of physical symptoms. Additionally, these agents may also have a role in modulating neurogenesis and other neuroplastic changes, thereby leading to more complete recovery in patients suffering from the emotional and physical symptoms of chronic depression.
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