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Viruses and tumours--an update.

Simon J Talbot¹, Dorothy H Crawford

¹Centre for Infectious Diseases, University of Edinburgh, R(D)SVS, Summerhall, Edinburgh EH9 1QH, UK. stalbot@ed.ac.uk

European Journal of Cancer (Oxford, England : 1990)

|August 19, 2004

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Infectious agents, particularly tumor-associated viruses, are linked to 15-20% of human cancers. This review updates knowledge on viral contributions to tumorigenesis since 1965.

Area of Science:

Oncology
Virology
Cancer Research

Background:

Significant advancements in understanding infectious agents' role in tumor development have occurred over 40 years.
Tumor-associated viruses are increasingly recognized as a significant factor in human malignancies.

Purpose of the Study:

To summarize current knowledge on tumor-associated viruses.
To contextualize recent findings within the historical perspective established by Harris (1965).

Main Methods:

Literature review and synthesis of research on viral oncogenesis.
Comparative analysis of current data against historical findings.

Main Results:

An estimated 15-20% of human cancers are attributed to infectious causes.

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Progress has been made in identifying specific viruses linked to various tumors.

Conclusions:

Infectious agents, especially viruses, play a crucial role in a substantial proportion of human cancers.
Continued research is vital for further understanding and potentially preventing virus-induced malignancies.