Indinavir increases glucose production in healthy HIV-negative men
Related Experiment Video
Updated: Aug 23, 2026

A Simple Flow Cytometric Method to Measure Glucose Uptake and Glucose Transporter Expression for Monocyte Subpopulations in Whole Blood
Published on: August 12, 2016
Jean-Marc Schwarz1, Grace A Lee, Seongsoo Park
1Department of Medicine, University of California, San Francisco, CA, USA.
Abstract:
In the absence of HIV infection, changes in adipose tissue and lipid levels, HIV protease inhibitor therapy increases fasting glucose levels,suggestive of hepatic insulin resistance. After 4 weeks of indinavir treatment in nine HIV-negative healthy men, fasting glucose production and glycogenolysis were significantly increased. During the euglycemic hyperinsulinemic clamp, indinavir blunted the ability of insulin to suppress glucose production. Therefore, indinavir worsens hepatic insulin sensitivity, increasing endogenous glucose production.
Related Concept Videos
Dipeptidyl Peptidase 4 Inhibitors
Oral Hypoglycemic Agents: Biguanides and Glitazones
Oral Hypoglycemic Agents: Glinides
Hyperglycemia
Inhibitors of Viral Protein Synthesis
Hormones Regulating Blood Glucose
In addition to accelerating glucose uptake and utilization, insulin has...
