Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypersensitivity pneumonitis.

Lawrence C Mohr1

  • 1Environmental Biosciences Program and Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA. mohrlc@musc.edu

Current Opinion in Pulmonary Medicine
|August 19, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Effects of Pleural Plaques on Longitudinal Lung Function in Vermiculite Miners of Libby, Montana.

The American journal of the medical sciences·2017
Same author

Longitudinal Lung Function Decrements in Firefighters Who Responded to the World Trade Center Disaster: Important Insights for the Preservation of Lung Function in Future Disasters.

Chest·2016
Same author

Lung Function before and after a Large Chlorine Gas Release in Graniteville, South Carolina.

Annals of the American Thoracic Society·2015
Same author

Reduced lung function in children associated with cesium 137 body burden.

Annals of the American Thoracic Society·2015
Same author

Response.

Chest·2015
Same author

Response.

Chest·2015

Hypersensitivity pneumonitis (HP) is an inflammatory lung disease caused by inhaling organic particles. Diagnosis relies on history and antigen avoidance, with corticosteroids used for severe or progressive cases.

Area of Science:

  • Pulmonary Medicine
  • Immunology
  • Environmental Health

Background:

  • Hypersensitivity pneumonitis (HP), or extrinsic allergic alveolitis, is a granulomatous lung disease triggered by inhaled organic antigens.
  • HP can manifest acutely, subacutely, or chronically, with chronic forms potentially leading to irreversible pulmonary fibrosis.
  • Understanding HP's pathogenesis and clinical course is crucial for effective management.

Purpose of the Study:

  • This review synthesizes current knowledge on the diagnosis, pathogenesis, and treatment of hypersensitivity pneumonitis.
  • To provide an updated overview of HP for clinicians and researchers.

Main Methods:

  • Review of current literature on hypersensitivity pneumonitis.
  • Discussion of diagnostic criteria, including history, serology, lavage, and biopsy.

Related Experiment Videos

  • Analysis of pathogenetic mechanisms and therapeutic strategies.

    • Main Results:

    • HP pathogenesis involves Type III and IV hypersensitivity reactions, with key cytokines like IFN-gamma, IL-10, TNF-alpha, and TGF-beta implicated.
    • Genetic factors, including specific HLA and TNF-alpha promoter polymorphisms, are associated with HP susceptibility in certain populations.
    • Diagnosis hinges on environmental/occupational history and antigen identification; supportive tests include serum antibodies, bronchoalveolar lavage, and lung biopsy.

    Conclusions:

    • Identifying and avoiding the causative organic antigen is paramount for HP management.
    • Corticosteroids are recommended for severe acute/subacute HP and severe/progressive chronic HP.
    • Long-term corticosteroid use for chronic HP requires documented objective improvement in clinical, functional, or radiographic parameters.