Magnetic resonance imaging in myocardial ischemia

MRI is a novel strategy to assess myocardial ischemia. It provides information on myocardial perfusion, viability, and potentially the extent of coronary artery disease. This technology may replace many of the current noninvasive and, perhaps, invasive techniques in the diagnosis and management of patients with coronary artery disease. This review aims to cover the major advances in cardiac MRI related to both diagnosis and therapy of myocardial ischemia.

Although improved image acquisition techniques have made it possible to obtain excellent image quality in most patients, powerful processing software has permitted the quantification of accurate and reproducible functional information regarding perfusion, wall motion, and viability. Stem cell delivery and gene therapy to the myocardium using cardiac MRI has been shown to be feasible. The use of 3-T systems for cardiac imaging and the imaging of atherosclerosis with MRI are currently being studied.

MRI is a highly accurate method of characterizing both reversible and irreversible myocardial injury and of obtaining information on myocardial viability. It has the ability to prognostic patients by evaluating ejection fraction and contractility. Robust and uncomplicated methodologies for coronary MR angiography are almost on the horizon. Quantification of several parameters used to diagnose, prognosticate, and follow patients with ischemic heart disease should be much easier in the future. It may, with the recent advances in imaging such as 3-T systems, provide major noninvasive diagnostic capability. Cardiac MRI, with its improved imaging, and its ability to treat and monitor various forms of invasive and noninvasive therapy, may attain its potential as a "one-stop shop" in the near future.