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Bone densitometry: which skeletal sites are best predicted by bone mass determinants?
Warren T K Lee1, Albert Y K Cheung, Joseph Lau
1Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, 5/F Clinical Sciences Building, Prince of Wales Hospital, Hong Kong, Shatin, PR China.
Journal of Bone and Mineral Metabolism
|August 19, 2004
Summary
This study identified lumbar spine and tibial bone mineral density (BMD) and content (BMC) as key predictors of bone mass in adolescent girls. Composite index scores were developed to simplify analysis of multisite bone mass data.
Area of Science:
- Pediatric bone health
- Adolescent skeletal development
- Bone densitometry
Background:
- Assessing bone mineral content/density (BMC/BMD) is crucial for understanding adolescent bone development.
- Identifying optimal skeletal sites for predicting BMC/BMD from determinants is unclear.
- Composite index scores can simplify analysis of multisite BMC/BMD data.
Purpose of the Study:
- To identify skeletal sites best predicted by bone mass determinants in healthy adolescent girls.
- To develop composite index scores from multisite BMC/BMD values for simplified analysis.
Main Methods:
- Dual-energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT) evaluated 11 BMC/BMD variables in 236 girls (12-15 years).
- Bone mass determinants (weight, height, puberty, diet, activity, turnover markers) were assessed.
- Factor analysis created composite index scores summarizing multisite BMC/BMD.
Main Results:
- Lumbar spinal BMD/BMC (DXA) and tibial integral BMD (pQCT) showed strongest prediction by determinants (R2: 0.57-0.77).
- Three composite index scores (areal BMD, areal BMC, vBMD) were derived.
- Composite scores demonstrated comparable predictive power to original variables (R2: 0.419-0.749).
Conclusions:
- Lumbar spine and tibial integral sites are optimal for bone mass evaluation in adolescents.
- Composite index scores effectively represent multisite BMC/BMD, reducing variable numbers for analysis.