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Bone densitometry in a patient with hypophosphatemic osteomalacia
Armando L Negri1, Cesar E Bogado, Jose R Zanchetta
1Instituto de Investigaciones Metabólicas, Libertad 836, 1 piso, 1012, Buenos Aires, Argentina. negri@casasco.com.ar
Journal of Bone and Mineral Metabolism
|August 19, 2004
Summary
This case study highlights how bone densitometry aids in diagnosing and monitoring hypophosphatemic osteomalacia. Early detection and treatment led to significant bone mineral density improvements.
Area of Science:
- Endocrinology
- Nephrology
- Bone Metabolism
Background:
- Osteomalacia is a bone disease characterized by inadequate mineralization.
- Hypophosphatemic osteomalacia results from a renal phosphate leak, leading to low serum phosphate levels.
Observation:
- A 60-year-old woman presented with bone pain and osteoporotic bone mineral density (BMD) measurements.
- Laboratory tests revealed low serum phosphate and elevated alkaline phosphatase, consistent with renal phosphate wasting.
Findings:
- The patient was diagnosed with hypophosphatemic osteomalacia and treated with phosphate and calcitriol.
- Treatment normalized serum phosphate, decreased alkaline phosphatase, and rapidly increased BMD, normalizing lumbar spine values within 10 months.
Implications:
- Bone densitometry is crucial for diagnosing and tracking treatment response in osteomalacia.
- Effective management of hypophosphatemic osteomalacia can lead to rapid bone mineral density recovery.