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Transient myocardial ischemia stimulates atrial natriuretic factor release
L S Malatino1, C Leonardi, B Stancanelli
1Istituto di Clinica Medica Luigi Condorelli, University of Catania, Italy.
American Heart Journal
|March 1, 1992
Summary
Transient myocardial ischemia, a condition often seen in coronary artery disease, triggers the release of atrial natriuretic factor. This hormone
Area of Science:
- Cardiology
- Endocrinology
- Physiology
Background:
- Atrial natriuretic factor (ANF) plays a role in cardiovascular homeostasis.
- Transient myocardial ischemia is a hallmark of symptomatic coronary artery disease (CAD).
- The relationship between ischemia-induced cardiac dysfunction and ANF release requires further elucidation.
Purpose of the Study:
- To investigate atrial natriuretic factor (ANF) release during transient myocardial ischemia in patients with coronary artery disease (CAD).
- To explore the correlation between ANF levels and hemodynamic changes, specifically pulmonary artery wedge pressure, during ischemia.
- To compare ANF release patterns during percutaneous transluminal coronary angioplasty (PTCA)-induced ischemia with those during angina.
Main Methods:
- Prospective study involving 29 patients with symptomatic CAD (Canadian Cardiovascular Association classes II-III).
- Group I (n=11) underwent percutaneous transluminal coronary angioplasty (PTCA); measurements included pulmonary artery wedge pressure and atrial natriuretic factor (ANF) levels at baseline and 2, 5, 15 minutes post-PTCA.
- Groups II and III experienced dye load and angina, respectively, with serial ANF measurements to compare release dynamics.
Main Results:
- Atrial natriuretic factor (ANF) levels significantly increased from baseline (34.6 +/- 4.5 pg/ml) to 56.3 +/- 7.3 pg/ml at 2 minutes post-PTCA (p = 0.02).
- ANF changes were strongly correlated with mean pulmonary artery wedge pressure changes (2 min: r = 0.69, p = 0.02; 5 min: r = 0.90, p < 0.001).
- ANF release during angina (Group III) occurred as early as after PTCA, suggesting ischemia is a potent stimulus.
Conclusions:
- Transient myocardial ischemia, whether induced by PTCA or occurring during angina, stimulates atrial natriuretic factor (ANF) release.
- The observed correlation suggests that changes in cardiac function, reflected by pulmonary artery wedge pressure, mediate ANF release during ischemia.
- These findings highlight ANF as a potential biomarker for ischemic events and associated cardiac dysfunction in CAD patients.