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Published on: July 30, 2011
A case of secondary diabetes mellitus with acromegaly improved by pioglitazone
A Watanabe1, F Komine, K Nirei
1Third Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan. 2315com@med.nihon-u.ac.jp
Aim:
The acromegaly patient was diagnosed with Type 2 diabetes mellitus. His HbA1c was 10.6% and fasting blood glucose (FBG) 15.3 mmol/l. We prescribed glibenclamide (10 mg/day), but his HbA1c and FBG remained high. At this stage, treatment with short-acting insulin was instigated at a dose of 20 U/day. However, the patient's blood glucose level remained unsatisfactory. We tried using pioglitazone.
Method:
Pioglitazone was prescribed at 30 mg/day in combination with the insulin.
Results:
The FBG and HbA1c value decreased to 7.2 mmol/l and 7.3%, respectively, within 2 months and insulin was discontinued. Pioglitazone alone was able to control the FBG level.
Conclusions:
Pioglitazone treatment might be considered as a choice for similar cases of diabetes secondary to acromegaly.
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