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Plasma brain natriuretic peptide in takotsubo cardiomyopathy

Y J Akashi1, H Musha, K Nakazawa

  • 1Department of Cardiology, St Marianna University, Yokohama-city Seibu Hospital, Yokohama, Japan. johnny@marianna-u.ac.jp

QJM : Monthly Journal of the Association of Physicians
|August 20, 2004
PubMed

Insights

Plasma brain natriuretic peptide (BNP) levels correlate with basal hyperkinesis severity in takotsubo cardiomyopathy. High BNP does not indicate a poor prognosis in these patients, unlike in other cardiac conditions.

Area of Science:

  • Cardiology
  • Internal Medicine

Background:

  • Takotsubo cardiomyopathy presents as reversible left ventricular dysfunction mimicking myocardial infarction but lacks coronary lesions.
  • Characterized by apical akinesis and basal hyperkinesis, it shows distinct left ventricular morphology.

Purpose of the Study:

  • To investigate plasma brain natriuretic peptide (BNP) concentrations in patients diagnosed with takotsubo cardiomyopathy.
  • To explore the relationship between BNP levels and specific echocardiographic parameters in this condition.

Main Methods:

  • Cardiac catheterization and blood collection for BNP measurement were performed on the first hospital day in ten takotsubo cardiomyopathy patients.
  • The deltaBase value, representing the difference in left ventricular diameter between systole and diastole, was measured to assess basal hyperkinesis.

Main Results:

  • Coronary angiography confirmed no significant stenosis in any patient.
  • Initial ejection fraction averaged 42.2%, cardiac index 1.90 L/min/m², and plasma BNP 522.5 pg/mL.
  • Plasma BNP showed a significant correlation with the deltaBase value, indicating a link to basal hyperkinesis severity.

Conclusions:

  • The initial deltaBase value serves as a reliable indicator of basal hyperkinesis severity in takotsubo cardiomyopathy.
  • Elevated BNP levels in takotsubo cardiomyopathy are not associated with a poor prognosis, distinguishing it from other cardiac diagnoses.
Abstract

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