Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sedentary death syndrome.

Simon J Lees1, Frank W Booth

  • 1Dept. of Biomedical Sciences, Univ. of Missouri-Columbia, Columbia, MO, USA.

Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquee
|August 20, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exercise training improves exercise capacity independent of AMPKα2 T172-mediated adaptations in skeletal muscle.

bioRxiv : the preprint server for biology·2026
Same author

Urea-based lysophosphatidic acid receptor 1 antagonists as potential migrastatics for triple-negative breast cancer.

Bioorganic chemistry·2026
Same author

Growth Restriction in Balb/c Mice Irradiated With X-Rays During Late Gestation: Role of Irradiation Timing, Dose Fractionation and Adaptive Response.

Dose-response : a publication of International Hormesis Society·2025
Same author

Plasma miRNAome Profiling Reveals Candidate Biomarkers for Low- and High-Dose Whole-Body Ionizing Radiation Exposure.

Dose-response : a publication of International Hormesis Society·2025
Same author

Gene Manipulation of Muscle Phenotype.

Advances in experimental medicine and biology·2025
Same author

Preclinical assessment of the selective androgen receptor modulator RAD140 to increase muscle mass and bone mineral density.

Physiological reports·2025
Same journal

[Habitual physical activity during growth].

Canadian journal of applied physiology = Revue canadienne de physiologie appliquee·2009
Same journal

Lifestyle modifications to prevent and manage hypertension for exercise physiologists and fitness professionals.

Canadian journal of applied physiology = Revue canadienne de physiologie appliquee·2006
Same journal

Performing triple and quadruple figure skating jumps: implications for training.

Canadian journal of applied physiology = Revue canadienne de physiologie appliquee·2006
Same journal

Estimation of the parameters of the relationship between power and time to exhaustion from a single ramp test.

Canadian journal of applied physiology = Revue canadienne de physiologie appliquee·2006
Same journal

Oxidative stress after three different intensities of running.

Canadian journal of applied physiology = Revue canadienne de physiologie appliquee·2006
Same journal

Effects of mild leg exercise in a seated position on haemostatic parameters under normobaric hypoxic conditions.

Canadian journal of applied physiology = Revue canadienne de physiologie appliquee·2006
See all related articles

Sedentary death syndrome (SeDS) poses a significant public health risk. Using physically active individuals as controls, rather than sedentary ones, is crucial for understanding the molecular causes of inactivity-related diseases like type 2 diabetes.

Area of Science:

  • Exercise physiology
  • Molecular biology
  • Public health

Background:

  • Sedentary death syndrome (SeDS) contributes to chronic diseases and premature mortality.
  • The molecular mechanisms underlying physical inactivity-induced chronic diseases remain poorly understood.
  • Type 2 diabetes (T2D) is a SeDS condition preventable by physical activity.

Purpose of the Study:

  • To investigate the molecular mechanisms of SeDS and physical inactivity.
  • To establish the role of physical inactivity in T2D development and progression.
  • To advocate for the use of physically active controls in SeDS research.

Main Methods:

  • Comparative analysis of molecular markers (e.g., GLUT4) between different subject groups.
  • Review of existing literature on physical inactivity and chronic disease.

Related Experiment Videos

  • Re-evaluation of control group selection in SeDS studies.

    • Main Results:

    • GLUT4 expression is higher in physically active individuals compared to sedentary and T2D groups.
    • Sedentary controls may lead to misleading interpretations of SeDS-related molecular changes.
    • Physically active controls provide a healthier baseline for comparison.

    Conclusions:

    • Physically active subjects are essential as control groups for accurate SeDS research.
    • Understanding molecular changes requires appropriate control selection.
    • This approach supports evidence-based prevention and therapy strategies for SeDS.