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No association of TAP2 polymorphisms in Korean patients with schizophrenia
Tae-Youn Jun1, Kyoung-Uk Lee, Chi-Un Pae
1Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Objectives:
Polymorphisms of transporters associated with antigen-processing (TAP) genes might influence the susceptibility to schizophrenia by altering the antigen-processing pathway. The aim of this study was to verify the relationship between schizophrenia and the polymorphisms of TAP2 genes.
Method:
Two hundred and fifty-seven Korean patients diagnosed with schizophrenia according to DSM-IV and 184 normal controls participated in this study. TAP2 polymorphic residues at positions 379, 565 and 665 were typed using amplification refractory mutation system-polymerase chain reaction single-strand conformation polymorphism.
Results:
Distribution of the alleles and genotypes in patients with schizophrenia was not significantly different from those of controls.
Conclusions:
This study did not show the association of the TAP2 gene with schizophrenia in the Korean population.
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