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Optimal dose regimen for paroxetine.

D L Dunner1, G C Dunbar

  • 1Department of Psychiatry, University of Washington, Seattle 98105.

The Journal of Clinical Psychiatry
|February 1, 1992
PubMed
Summary
This summary is machine-generated.

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The recommended starting dose for paroxetine is 20 mg daily, which is also the minimal effective dose for depression treatment. Dosage adjustments up to 50 mg daily may be necessary for non-responders, with specific considerations for elderly patients.

Area of Science:

  • Pharmacology
  • Clinical Psychiatry
  • Drug Dosing

Background:

  • Paroxetine is a widely used antidepressant medication.
  • Establishing optimal dosing is crucial for effective depression treatment.
  • Previous studies have informed paroxetine's therapeutic use.

Purpose of the Study:

  • To summarize the established dose regimen for paroxetine in depression treatment.
  • To provide guidance on initiating and adjusting paroxetine dosage.
  • To outline specific dosing considerations for the elderly population.

Main Methods:

  • Analysis of individual dosing studies.
  • Review of worldwide clinical data for paroxetine.
  • Synthesis of established therapeutic guidelines.

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Main Results:

  • The minimal and often optimal starting dose is 20 mg/day.
  • Dose increases of 10 mg/week are recommended for non-responders, up to a maximum of 50 mg/day.
  • The therapeutic dose range for elderly patients is 20-40 mg/day.

Conclusions:

  • The paroxetine dose regimen for depression is well-defined.
  • Flexible dosing allows for individualized treatment based on patient response.
  • Specific guidelines exist for elderly patients to ensure safe and effective treatment.