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[Abdominal pain and recurrent cholestatic jaundice]
F Livio Ndiaye1, P H Wiesel, J J Goy
1Centre Hospitalier Universitaire Vaudois, Lausanne. francoise.livio@chuv.hospvd.ch
Praxis
|August 21, 2004
Summary
A 70-year-old heart and renal transplant patient experienced abdominal pain and jaundice after colchicine therapy. Symptoms resolved upon drug withdrawal, suggesting a possible adverse drug reaction.
Area of Science:
- Pharmacology
- Hepatology
- Transplant Medicine
Background:
- Colchicine is commonly used for various inflammatory conditions.
- Heart and renal transplant recipients may have altered drug metabolism.
- Drug-induced liver injury is a potential complication of many medications.
Observation:
- A 70-year-old male heart and renal transplant recipient presented with recurrent acute abdominal pain.
- Jaundice, inflammatory syndrome, and cholestasis were noted during hospitalization.
- Symptoms improved significantly after discontinuation of colchicine therapy.
Findings:
- Extensive investigations for other causes of abdominal pain and cholestasis were negative.
- A strong temporal association existed between colchicine administration and symptom onset.
- Adverse drug reaction to colchicine was suspected as the most probable cause.
Implications:
- This case highlights the potential for colchicine to cause hepatotoxicity and cholestasis in transplant patients.
- Clinicians should consider colchicine-induced liver injury in transplant recipients presenting with similar symptoms.
- Further research may be warranted to elucidate the mechanisms of colchicine hepatotoxicity in this population.
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