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Updated: Jul 16, 2026
09:16
Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing
Published on: February 16, 2017
Intravenous subhypnotic propofol in central pain: a double-blind, placebo-controlled, crossover study
1Turin Advanced Neuromodulation Group, Turin, Italy. solara@infinito.it
Clinical Neuropharmacology
|August 21, 2004
Summary
Subhypnotic doses of propofol, a gamma-aminobutyric acid A (GABA-A) agonist, effectively reduced central pain and allodynia in patients. This study validates propofol as a potential diagnostic tool for central pain conditions.
Area of Science:
- Neuroscience
- Anesthesiology
- Pain Management
Background:
- Central pain is a debilitating condition often resulting from damage to the central nervous system.
- Current diagnostic and therapeutic options for central pain are limited.
- The gamma-aminobutyric acid A (GABA-A) system is implicated in pain modulation.
Purpose of the Study:
- To evaluate the efficacy of subhypnotic intravenous (IV) propofol as a diagnostic test for central pain.
- To assess the impact of propofol on spontaneous ongoing pain and allodynia.
- To explore the role of GABA-A modulation in central pain.
Main Methods:
- A double-blind, placebo-controlled, crossover study was conducted.
- 44 patients with chronic central pain (brain and cord origin) received a 0.2 mg/kg IV bolus of propofol or placebo (Intralipid).
- Pain intensity and allodynia were assessed before and after drug administration.
Main Results:
- Propofol significantly reduced spontaneous ongoing pain in 55% of patients compared to 14% receiving placebo.
- Propofol also significantly decreased mechanical and cold allodynia.
- Side effects were minimal, including temporary burning on injection and mild lightheadedness.
Conclusions:
- Systemic propofol demonstrates significant analgesic effects on spontaneous pain and allodynia in central pain conditions.
- These findings support the role of GABA-A modulation in central pain.
- Propofol shows promise as a diagnostic agent for central pain.
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