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PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
Published on: December 27, 2013
Water soluble vitamin E (TMG) as a radioprotector
Cherupally Krishnan K Nair1, Pathirissery Uma Devi, R Shimanskaya
1Radiation Biology Division, Bhabha Atomic Research Centre, Mumbai 400085, India.
Indian Journal of Experimental Biology
|August 24, 2004
Summary
Tocopherol monoglucoside (TMG), a vitamin E derivative, acts as an antioxidant to shield biological systems from radiation damage. This compound demonstrates significant radioprotective effects in various in vitro and in vivo models.
Area of Science:
- Biochemistry
- Radiation Biology
- Pharmacology
Background:
- Tocopherol monoglucoside (TMG) is a water-soluble vitamin E derivative.
- Ionizing radiation causes significant damage to biological systems.
- Antioxidants are crucial for mitigating radiation-induced cellular damage.
Purpose of the Study:
- To evaluate the radioprotective potential of Tocopherol monoglucoside (TMG).
- To investigate TMG's antioxidant and free radical scavenging properties.
- To assess TMG's efficacy in preventing radiation-induced biological damage in vitro and in vivo.
Main Methods:
- Assessed TMG's antioxidant activity and free radical scavenging capacity.
- Investigated TMG's protective effects against DNA strand breaks and thymine glycol formation induced by gamma radiation.
- Evaluated TMG's ability to prevent radiation-induced loss of tumor cell viability and lipid peroxidation.
- Determined TMG's toxicity and pharmacokinetic profile in mice and rats.
- Assessed TMG's efficacy in protecting against radiation-induced embryonic mortality and lethality in mice.
Main Results:
- TMG demonstrated potent antioxidant and free radical scavenging activity, forming a phenoxyl radical.
- TMG effectively protected DNA from radiation-induced strand breaks and thymine glycol formation.
- TMG prevented gamma-radiation-induced loss of tumor cell viability and lipid peroxidation in cellular membranes.
- TMG exhibited low toxicity in mice (oral LD50 > 7.0 g/kg; ip LD50 = 1.15 g/kg) with rapid absorption and elimination in rats.
- TMG significantly reduced radiation-induced embryonic mortality by 75% and increased the LD50(30) in mice exposed to gamma radiation.
Conclusions:
- TMG is a potent antioxidant and effective radioprotective agent against ionizing radiation.
- TMG offers significant protection to biological systems from radiation-induced damage, including DNA damage, cell death, and lethality.
- TMG's low toxicity and favorable pharmacokinetic profile suggest its potential therapeutic application in radiation protection.
