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Updated: Aug 22, 2026

Isolation of Primary Patient-specific Aortic Smooth Muscle Cells and Semiquantitative Real-time Contraction Measurements In Vitro
Published on: February 15, 2022
Deoxyribozymes as inhibitors of vascular smooth muscle cell growth
1Centre for Vascular Research, University of New South Wales and Department of Haematology, The Prince of Wales Hospital, Sydney, Australia. L.Khachigian@unsw.edu.au
Abstract:
DNA enzymes, or DNAzymes, are all-DNA molecules with inherent catalytic activity that bind and cleave at their complementary sequence in the target mRNA through Watson-Crick base pairing. These agents have been successfully used to tease out the role the targeted gene plays in both cellular systems and in a variety of animal models. DNAzymes have the potential to serve as novel nucleic acid-based therapeutic agents in pathologies involving aberrant smooth muscle cell growth and a range of other disorders.
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