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Nondiabetic ketoacidosis caused by severe hyperthyroidism
Emily T Wood1, William B Kinlaw
1Department of Medicine, Division of Endocrinology and the Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire, USA.
Thyroid : Official Journal of the American Thyroid Association
|August 24, 2004
Summary
Severe hyperthyroidism can cause ketoacidosis, a condition not typically associated with thyroid hormone excess. This finding suggests adding thyrotoxicosis to the differential diagnosis for unexplained ketoacidosis.
Area of Science:
- Endocrinology
- Metabolic Disorders
Background:
- Ketoacidosis is commonly linked to diabetes mellitus.
- Severe hyperthyroidism's role in ketoacidosis is not well-established.
Observation:
- A patient with severe hyperthyroidism presented with unexplained ketoacidosis.
- Thyroid hormone's known lipolytic and hepatic effects were noted.
Findings:
- Thyrotoxicosis was identified as a significant contributing factor to the patient's ketoacidosis.
- This case highlights a potential link between severe hyperthyroidism and ketoacidosis.
Implications:
- Severe hyperthyroidism should be considered in the differential diagnosis of ketoacidosis.
- Further research is warranted to understand the mechanisms linking thyrotoxicosis and ketoacidosis.