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[Programmed stimulation for in vitro fertilization].

B Imthurn1, E Macas, E Hotz

  • 1Departement für Frauenheilkunde, Universitätsspital, Zürich, Schweiz.

Geburtshilfe Und Frauenheilkunde
|January 1, 1992
PubMed
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This study optimized in vitro fertilization (IVF) protocols to schedule oocyte retrieval Tuesday-Friday. Individualized stimulation significantly improved oocyte yield and pregnancy rates compared to a preliminary protocol.

Area of Science:

  • Reproductive Medicine
  • Gynecology
  • Endocrinology

Background:

  • Current in vitro fertilization (IVF) protocols often require flexible scheduling for oocyte retrieval.
  • Optimizing the timing of oocyte aspiration can improve laboratory efficiency and patient convenience.
  • Previous protocols lacked a structured approach to synchronize oocyte retrieval within a specific timeframe.

Purpose of the Study:

  • To evaluate a programmed stimulation protocol for IVF to enable oocyte aspiration exclusively from Tuesday to Friday.
  • To compare the efficacy of a standardized stimulation protocol (Group A) versus an individualized protocol (Group B).

Main Methods:

  • A programmed protocol involved norethisterone acetate followed by D-Trp-6-LHRH and HMG (human menopausal gonadotropin).

Related Experiment Videos

  • Group A used a fixed HMG dose (150 IU/d), while Group B utilized individualized HMG dosing and initiation.
  • Oocyte aspiration was performed via transvaginal ultrasound; IVF outcomes were compared between groups.

    • Main Results:

    • The individualized protocol (Group B) significantly reduced cycle cancellation rates (3% vs. 33%, p < 0.025).
    • Group B yielded more oocytes per aspiration (7.8 vs. 5.3, p < 0.05) with a higher cleavage rate (74% vs. 62%).
    • Clinical pregnancy rates in Group B reached 30% per stimulation cycle (p < 0.05).

    Conclusions:

    • The programmed stimulation protocol, particularly with individualized HMG treatment, effectively enables oocyte retrieval within a Tuesday-Friday window.
    • This optimized protocol significantly enhances IVF success rates, including oocyte yield and clinical pregnancy.
    • The findings support the implementation of this protocol for improved efficiency and outcomes in IVF programs.