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Promotion of Survival and Differentiation of Neural Stem Cells with Fibrin and Growth Factor Cocktails after Severe Spinal Cord Injury
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Spinal anaesthesia and dysfibrinogenaemia

D J Meldrum1, G Evans, P Popham

  • 1Department of Haematology, Addenbrooke's Hospital, Cambridge, UK.

International Journal of Obstetric Anesthesia
|August 24, 2004
PubMed

We report the case of a 34-year-old woman who presented to the delivery unit at 36 weeks' gestation with spontaneous rupture of membranes. She had a triplet pregnancy following in vitro fertilisation. An elective caesarean section was performed under spinal anaesthesia 4h after admission. The patient had a massive postpartum haemorrhage in the recovery area at which time she mentioned that she was known to have 'low fibrinogen'. Further investigation showed that she suffered from dysfibrinogenaemia, as did several members of her family. We can find no reported cases of the use of central neural blockade in a patient with untreated dysfibrinogenaemia. Central neural blockade is often considered contraindicated in patients with disorders of fibrinogen; there were fortunately no neurological sequelae following spinal anaesthesia in this patient.

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