[HLA-Cw alleles polymorphism and haplotypes in Guangdong Han population]
Hong-jing Ma1, Lu-lu Xiao, Xiao-lin Yin
1Department of Hematology, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China.
Objective:
To analyze the polymorphism and haplotypes of HLA-Cw and detect HLA-A, B, Cw and DRB1 allele frequencies in Guangdong Han population.
Method:
An auto semi-quantitative PCR with reverse sequence-specific oligonucleo- tide was adopted to explore the HLA-A, B, Cw and DRB1 genotypes of 185 bone marrow donors.
Result:
Eleven HLA-Cw alleles were obtained in which Cw*03 (0.2580), 07 (0.1887), 01 (0.1732), and 08 (0.1071) had much higher allele frequencies. A total of 7 HLA-Cw-A, 20 HLA-Cw-B and 10 HLA-Cw-DRB1 haplotypes were found.
Conclusion:
HLA-Cw alleles have richer polymorphisms and their linkage disequilibrium with HLA-A, B, DRB1 exhibits geographic genetic characteristics.
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