Gastric transcription profile of Helicobacter pylori infection in the rhesus macaque
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Updated: Aug 22, 2026
Mouse Models Of Helicobacter Infection And Gastric Pathologies
Published on: October 18, 2018
Jennifer L Huff1, Lori M Hansen, Jay V Solnick
1Department of Medical Microbiology and Immunology, Center for Comparative Medicine, University of California, Davis, Davis, CA 95616, USA. jlmshuff@ucdavis.edu
Abstract:
Infection with Helicobacter pylori is usually asymptomatic but sometimes progresses to peptic ulcer disease or gastric adenocarcinoma. The development of disease involves both host and bacterial factors. In order to better understand host factors in pathogenesis, we studied the gastric transcription profile of H. pylori infection in the rhesus macaque by using DNA microarrays. Significant changes were found in the expression of genes important for innate immunity, chemokines and cytokines, cell growth and differentiation, apoptosis, structural proteins, and signal transduction and transcription factors. This broad transcription profile demonstrated expected up-regulation of cell structural elements and the host inflammatory and immune response, as well as the novel finding of down-regulation of heat shock proteins. These results provide a unique view of acute H. pylori infection in a relevant animal model system and will direct future studies regarding the host response to H. pylori infection.
Insights
Helicobacter pylori infection alters host gene expression in the stomach, impacting immunity and cell processes. This study reveals novel insights into the host response during acute infection.
Area of Science:
- Gastroenterology
- Microbiology
- Immunology
Background:
- Helicobacter pylori infection is a common cause of peptic ulcer disease and gastric cancer.
- Disease development involves complex interactions between host and bacterial factors.
- Understanding host genetic responses is crucial for elucidating pathogenesis.
Purpose of the Study:
- To investigate the gastric transcription profile during acute Helicobacter pylori infection.
- To identify host genes and pathways affected by H. pylori infection in a relevant animal model.
- To gain insights into host factors contributing to H. pylori-associated diseases.
Main Methods:
- Utilized DNA microarrays to analyze the gastric transcription profile in rhesus macaques infected with H. pylori.
- Compared gene expression patterns between infected and control subjects.
- Focused on changes in genes related to immunity, cell regulation, and structural components.
Main Results:
- Identified significant alterations in the expression of genes involved in innate immunity, chemokines, cytokines, cell growth, apoptosis, and signal transduction.
- Observed expected up-regulation of genes related to cell structure and the host inflammatory/immune response.
- Discovered a novel down-regulation of heat shock proteins during acute H. pylori infection.
Conclusions:
- The study provides a comprehensive view of the host transcriptional response to acute H. pylori infection in a rhesus macaque model.
- Findings highlight the intricate host-pathogen interactions influencing disease development.
- The identified gene expression changes offer potential targets for future research on H. pylori pathogenesis and host-directed therapies.
