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Model of local temperature changes in brain upon functional activation.

Christopher M Collins1, Michael B Smith, Robert Turner

  • 1Center for NMR Research, Dept. of Radiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA. cmcollins@psu.edu

Journal of Applied Physiology (Bethesda, Md. : 1985)
|August 24, 2004
PubMed
Summary

Numerical models show brain temperature changes during functional activation are complex, potentially increasing or decreasing. Perfusion significantly impacts temperature, with active brain tissue approaching blood temperature, within experimental ranges.

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Area of Science:

  • Neuroscience
  • Biophysics
  • Computational Biology

Background:

  • Experimental measurements of brain temperature changes during functional activation exhibit significant variability.
  • Accurate numerical modeling is crucial for understanding these temperature dynamics.

Purpose of the Study:

  • To develop and utilize a 3D numerical model of human head temperature.
  • To investigate potential temperature changes in the brain due to functional activation.

Main Methods:

  • Employed the bioheat equation, incorporating metabolism, perfusion, and thermal conduction.
  • Simulated temperature variations in the human head under functional activation.

Main Results:

  • Brain temperature can increase or decrease upon activation, influenced by location and baseline temperature relative to blood temperature.

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  • Increased perfusion has a more substantial effect on temperature than increased metabolism.
  • Simulated temperature changes are within 0.12 degrees C, aligning with experimental findings.

    • Conclusions:

    • The model predicts active brain regions approach blood temperature.
    • Numerical simulations provide a framework for understanding brain thermal responses.
    • Model predictions are consistent with experimental observations in human subjects.