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Updated: Aug 22, 2026

Study of Protein-protein Interactions in Autophagy Research
Published on: September 9, 2017
Glutamate receptor-interacting protein 1 protein binds to the microtubule-associated protein
1Department of Biochemistry, College of Medicine, Inje University, Busan 614-735, Korea. daehyun@ijnc.inje.ac.kr
Abstract:
To identify the interaction proteins for the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor subunit glutamate receptor-interacting protein 1 (GRIP1), GRIP1 interactions with microtubule-associated protein (MAP)-1B light chain (LC) were investigated. GRIP1 interacts with MAP-1A and MAP-1B in the yeast two-hybrid assay, as is indicated also by glutathione S-transferase (GST) pull-down and coimmunoprecipitation with MAP-1B LC antibody in brain fractions. These results suggest a novel mechanism for localizing AMPA receptors to synaptic sites.
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