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Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training
07:40

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training

Published on: October 10, 2019

Cardiac troponin T and end stage renal disease

Alaa-Eldin M Gabr1, Ibrahim A Ibrahim, Shaza M Aloulou

  • 1Department of Internal Medicine, King Fahd Specialist Hospital, PO Box 2290, Buraidah, Kingdom of Saudi Arabia. souhad2000@hotmail.com

Saudi Medical Journal
|August 24, 2004
PubMed

Insights

Serum cardiac troponin T (cTnT) levels may be altered by hemodialysis in end-stage renal disease (ESRD) patients. Elevated cTnT is a specific marker for subclinical myocardial damage in ESRD patients undergoing dialysis.

Area of Science:

  • Cardiology
  • Nephrology
  • Clinical Biochemistry

Background:

  • End-stage renal disease (ESRD) patients on chronic hemodialysis (HD) have a high prevalence of ischemic heart disease (IHD).
  • Accurate assessment of cardiac damage in ESRD patients is challenging due to various confounding factors.

Purpose of the Study:

  • To investigate the relationship between serum cardiac troponin T (cTnT) and other cardiac markers and IHD in ESRD patients on chronic HD.
  • To determine the specificity of cTnT as a biochemical marker for subclinical myocardial damage in this population.

Main Methods:

  • Serum cTnT levels were measured in 73 ESRD patients undergoing chronic HD using the Elecsys 2020 immunoassay system.
  • Patients were categorized into groups based on history of IHD, diabetes, or both, and controls without evidence of myocardial damage.
  • cTnT concentrations were analyzed in pre- and post-hemodialysis samples.

Main Results:

  • Elevated cTnT levels (>=0.1 ug/L) were observed in 58% of HD patients.
  • Increased cTnT was noted in 53% of diabetic patients, 37% of IHD patients, 59% of patients with both diabetes and IHD, and 29% of controls.
  • cTnT levels were more frequently elevated in post-hemodialysis samples (21%) compared to pre-hemodialysis samples (13%).

Conclusions:

  • Hemodialysis may influence measured cTnT concentrations in ESRD patients.
  • Elevated cTnT, whether sporadic or persistent, appears to be a specific biochemical marker for predicting subclinical myocardial damage in ESRD patients.
Abstract

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