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Thyroid dysfunction in patients with type 2 diabetes mellitus in Jordan
Abdel-Rahman M Radaideh1, Mohamad K Nusier, Fawaz L Amari
1National Center of Diabetes, Endocrinology and Genetics, Jordan University of Science and Technology, School of Medicine, Irbid, Jordan.
Saudi Medical Journal
|August 24, 2004
Summary
Type 2 diabetes patients have a higher prevalence of thyroid dysfunction. Screening for thyroid issues in diabetic individuals is recommended to detect asymptomatic conditions early.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Thyroidology
Background:
- Type 2 diabetes mellitus (T2DM) is a global health concern.
- Thyroid dysfunction can impact metabolic control.
- The relationship between T2DM and thyroid autoimmunity requires further investigation.
Purpose of the Study:
- To determine the prevalence of thyroid dysfunction and autoimmunity in patients with type 2 diabetes.
- To compare thyroid disease rates in T2DM patients versus non-diabetic controls.
Main Methods:
- A cohort of 908 type 2 diabetic patients and 304 non-diabetic controls were recruited.
- Thyroid function tests (FT4, FT3, TSH) were performed.
- Thyroid autoantibodies, including thyroid peroxidase antibodies (TPOab) and thyroglobulin antibodies (Tgab), were assessed in a subset of participants.
Main Results:
- Overall thyroid disease prevalence was 12.5% in T2DM patients, significantly higher than the 6.6% in controls (p=0.0064).
- Subclinical hypothyroidism was the most common thyroid dysfunction in both groups.
- While TPOab positivity was similar, combined TPOab and Tgab positivity was lower in T2DM patients (2.5%) compared to controls (6%, p=0.0155).
Conclusions:
- Diabetic patients exhibit a higher prevalence of thyroid dysfunction.
- Screening for asymptomatic thyroid dysfunction in type 2 diabetes patients is warranted.
- Further research may explore the specific mechanisms linking T2DM and thyroid autoimmunity.