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Mutactimycin PR, a new anthracycline antibiotic from Saccharothrix sp. SA 103. II. Physico-chemical properties and
Abdelghani Zitouni1, Florence Mathieu, Yannick Coppel
1Ecole Nationale Supérieure d'Agronomie de Toulouse, INPT, Laboratoire de Génie Chimique, UMR 5503 (CNRS/INPT/UPS), 1, avenue de l'Agrobiopôle, B.P. 107, F-31 326 Castanet-Tolosan Cedex, France.
Abstract:
A new antibiotic termed mutactimycin PR (1) was isolated along with the known mutactimycin C (2) from the fermentation broth of Saccharothrix sp. SA 103. The two compounds belong to the anthracycline group. The structure of these antibiotics was elucidated with the aid of NMR and mass spectrometric investigations. The novel compound mutactimycin PR was characterized as 5,12 Naphtacenedione, 7-[(6-deoxy-3-O-methyl-alpha-L-mannopyranosyl)oxy]-4-[(6-deoxy-alpha-L-mannopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-9 methyl.
