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Published on: April 19, 2017
YM-215343, a novel antifungal compound from Phoma sp. QN04621
Mitsuyoshi Shibazaki1, Masatoshi Taniguchi, Takako Yokoi
1Microbiology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd., 1-1-8 Azusawa, Itabashi-ku, Tokyo 174-8511, Japan. shibazak@yamanouchi.co.jp
Abstract:
Through our screening for novel antifungal compounds, YM-215343 was found in the culture extract of Phoma sp. QN04621. The structure of YM-215343 was determined by several spectroscopic experiments as a novel compound closely related to apiosporamide and fischerin. YM-215343 exhibited antifungal activity against the pathogenic fungi, Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus with MIC values of 2 to approximately 16 microg/ml. It also showed cytotoxicity against HeLa S3 cells with an IC50 of 3.4 microg/ml.
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Antifungal Agents
Fungal Group Zygomycota
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