Jove
Visualize
Contact Us

Related Experiment Videos

Current trends in asthma therapy.

Krzysztof Sztanke1, Kazimierz Pasternak

  • 1Department of Synthesis and Technology of Drugs, Medical University of Lublin.

Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina
|August 25, 2004
PubMed
Summary

For persistent asthma, inhaled corticosteroids are first-line treatment. Combining inhaled corticosteroids with long-acting beta2-agonists improves lung function and quality of life, with budesonide/formoterol showing faster bronchodilation than salmeterol/fluticasone.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biological and thermal studies on imidazoline/dimethyl pentanedioate hybrids connected via a hydrazinylidene linker.

Scientific reports·2026
Same author

Thermal Characterisation and Toxicity Profile of Potential Drugs from a Class of Disubstituted Heterofused Triazinones.

Molecules (Basel, Switzerland)·2025
Same author

Biomimetic Chromatography/QSAR Investigations in Modeling Properties Influencing the Biological Efficacy of Phenoxyacetic Acid-Derived Congeners.

Molecules (Basel, Switzerland)·2025
Same author

In Vitro, In Vivo, Ex Vivo Characterisation of Dihydroimidazotriazinones and Their Thermal Decomposition Course Studied by Coupled and Simultaneous Thermal Analysis Methods.

International journal of molecular sciences·2025
Same author

First voltammetric analysis of two possible anticancer drug candidates using an unmodified glassy carbon electrode.

Scientific reports·2024
Same author

Studies on the Thermal Decomposition Course of Nitrogen-Rich Heterocyclic Esters as Potential Drug Candidates and Evaluation of Their Thermal Stability and Properties.

International journal of molecular sciences·2024
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Pulmonology
  • Pharmacology

Background:

  • Asthma is a chronic airway inflammatory disease requiring long-term management.
  • Inhaled corticosteroids (ICS) are the primary treatment for persistent asthma.
  • For uncontrolled asthma on ICS, adding a long-acting inhaled beta2-agonist (LABA) is recommended over increasing ICS dosage.

Purpose of the Study:

  • To evaluate the efficacy of combined ICS and LABA inhaler devices for asthma management.
  • To compare the effectiveness of budesonide/formoterol with salmeterol/fluticasone combinations.

Main Methods:

  • Review of clinical studies on ICS/LABA combination therapies.
  • Comparison of lung function improvement, quality of life, and exacerbation rates.
  • Assessment of onset of bronchodilation for different combination inhalers.

Main Results:

  • ICS/LABA combination therapy improves lung function and quality of life while reducing asthma exacerbations.
  • Both salmeterol/fluticasone and budesonide/formoterol are effective in controlling asthma.
  • Budesonide/formoterol demonstrated a faster onset of bronchodilation compared to salmeterol/fluticasone.

Conclusions:

  • Combined ICS/LABA inhalers offer a valuable therapeutic option for persistent asthma.
  • The choice of ICS/LABA combination may influence the speed of symptom relief.
  • Budesonide/formoterol provides a rapid bronchodilatory effect, potentially offering quicker relief for asthmatic patients.

Related Experiment Videos