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The distribution of cis- and trans-acitretin in human epidermis
E Meyer1, W Lambert, A De Leenheer
1Laboratoria voor Medische Biochemie en voor Klinische Analyse, Gent, Belgium.
Abstract:
The concentrations of trans-acitretin and its principal metabolite, cis-acitretin, were measured by h.p.l.c. after single and multiple dosing (50 mg orally for 13 days) in plasma, blister fluid and epidermal samples from four healthy male volunteers. Within-day epidermal concentrations of trans-acitretin exceeded those of the cis-form which were at the limit of assay sensitivity. No accumulation of trans-acitretin was observed in plasma or blister fluid but AUC values for the drug in blister roof cells tended to be higher after multiple dosing.
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