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[Cardiac function and the skin microcirculation in acromegaly].

R Bach1, E Leicht, H J Langer

  • 1Abteilung Innere Medizin III, Medizinische Universitätsklinik, Universität Homburg.

Deutsche Medizinische Wochenschrift (1946)
|March 27, 1992
PubMed
Summary

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Nail-fold capillary video microscopy did not effectively distinguish acromegaly treatment success. Abnormal heart function in acromegaly patients was not linked to impaired capillary blood flow.

Area of Science:

  • Endocrinology
  • Cardiology
  • Microcirculation Research

Context:

  • Acromegaly, a condition of excess growth hormone, can lead to cardiovascular complications.
  • Assessing microcirculatory function is crucial for understanding disease impact and treatment efficacy.

Purpose:

  • To evaluate the utility of nail-fold capillary video microscopy in assessing microcirculatory function in acromegaly patients.
  • To determine if microcirculatory parameters correlate with disease activity or cardiovascular abnormalities in acromegaly.

Summary:

  • Nail-fold capillary video microscopy parameters (capillary density, torque index, reactive hyperemia, epidermal blood flow) were assessed in 21 acromegaly patients.
  • Elevated growth hormone and somatomedin C levels were observed in 10 patients despite prior treatment.

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  • Cardiac abnormalities, including myocardial thickness increase and left ventricular dysfunction, were present in several patients, independent of hypertension.
  • Microscopy findings did not differentiate between successfully treated and untreated patients or correlate with disease duration.

    • Impact:

    • Nail-fold capillary video microscopy may not be a sensitive tool for monitoring acromegaly treatment response or microcirculatory status.
    • Abnormal cardiac function in acromegaly is not primarily caused by inadequate capillary blood flow.
    • Further research is needed to identify reliable biomarkers for microcirculatory changes and cardiovascular risk in acromegaly.