Related Experiment Videos
Autosomal dominant palmoplantar hyperkeratosis and sensorineural deafness in three generations
M Sharland1, N R Bleach, P D Goberdhan
1Department of Genetics, St George's Hospital Medical School, London.
Journal of Medical Genetics
|January 1, 1992
Abstract:
A family is presented with autosomal dominant progressive palmoplantar hyperkeratosis, which is invariably associated with a slowly progressive, bilateral, high frequency, sensorineural hearing loss. The family show no other ectodermal abnormality. The differential diagnosis and possible mechanisms are discussed. This family appears to represent a unique variant in the hyperkeratosis-deafness association.