Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Scaling and hierarchical structures in DNA sequences.

Zhengqing Ouyang1, Chao Wang, Zhen-Su She

  • 1State Key Lab for Turbulence and Complex Systems and Center for Theoretical Biology, Peking University, Beijing 100871, China.

Physical Review Letters
|August 25, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synthesis and anti-nociceptive and anti-inflammatory effects of gaultherin and its analogs.

Journal of Asian natural products research·2011
Same author

[ATM/H2AX and repair of sperm-DNA damage during cryopreservation].

Zhonghua nan ke xue = National journal of andrology·2011
Same author

Predicting accident frequency at their severity levels and its application in site ranking using a two-stage mixed multivariate model.

Accident; analysis and prevention·2011
Same author

Photothermally enhanced photodynamic therapy delivered by nano-graphene oxide.

ACS nano·2011
Same author

[Characteristics of soil respiration in Phyllostachys edulis forest in Wanmulin Natural Reserve and related affecting factors].

Ying yong sheng tai xue bao = The journal of applied ecology·2011
Same author

Quality changes in sea urchin (Strongylocentrotus nudus) during storage in artificial seawater saturated with oxygen, nitrogen and air.

Journal of the science of food and agriculture·2011

We introduce a new method to analyze DNA correlation structure. Our findings reveal that nucleotide density fluctuations exhibit self-similarity scaling, with a parameter beta quantifying genome organizational complexity.

Area of Science:

  • Genomics
  • Bioinformatics
  • Statistical Physics

Background:

  • Understanding DNA sequence organization is crucial for genomics.
  • Previous models have not fully captured large-scale correlations in DNA.

Purpose of the Study:

  • To introduce a novel method for analyzing DNA correlation structure.
  • To quantify large-scale correlations and organizational complexity in genomes.

Main Methods:

  • Analysis of nucleotide density fluctuations.
  • Application of the She-Leveque hierarchical structure model.
  • Comparison with shuffled and simulated DNA sequences.

Main Results:

  • Nucleotide density fluctuations show extended self-similarity scaling (100-8000 base pairs).

Related Experiment Videos

  • The parameter beta quantifies correlations present in true DNA but absent in random or simulated sequences.
  • Beta varies with genome evolution category, reflecting organizational complexity.

    • Conclusions:

    • The introduced method accurately describes DNA correlation structure.
    • The parameter beta serves as a robust measure of genomic organizational complexity.
    • This approach offers insights into genome evolution and organization.