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[Thyroid function in children with Down's syndrome]
M L Colombo1, G Bona, P Quaglia
1Divisione Universitaria di Pediatria, Ospedale S. Luigi Gonzaga, Orbassano, Torino.
Minerva Pediatrica
|January 1, 1992
Summary
Down syndrome (trisomy 21) patients show an increased risk of thyroid disorders, particularly hypothyroidism. Early clinical and endocrinological follow-up is crucial for timely diagnosis and management in these children.
Area of Science:
- Endocrinology
- Genetics
- Pediatrics
Context:
- Down syndrome (trisomy 21) is a genetic condition associated with various health complications.
- Thyroid dysfunction is a known concern in the Down syndrome population.
- Evaluating thyroid function is essential for comprehensive patient care.
Purpose:
- To assess thyroid function in patients with Down syndrome.
- To investigate the prevalence of thyroid disorders in trisomy 21.
- To determine the association between Down syndrome and thyroid dysfunction.
Summary:
- The study evaluated 45 Down syndrome patients for thyroid function.
- One case of subclinical hypothyroidism was diagnosed in 28 subjects.
- Transient neonatal hyperthyrotropinemia was observed in one infant; others were euthyroid.
- Altered thyroid functions were noted in children with trisomy 21 and heart anomalies.
Impact:
- Highlights the increased risk of thyroid disorders in Down syndrome.
- Recommends regular clinical and endocrinological monitoring for early detection.
- Emphasizes the importance of managing thyroid dysfunction to improve outcomes in trisomy 21.