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[Thyroid function in children with Down's syndrome].

M L Colombo1, G Bona, P Quaglia

  • 1Divisione Universitaria di Pediatria, Ospedale S. Luigi Gonzaga, Orbassano, Torino.

Minerva Pediatrica
|January 1, 1992
PubMed
Summary
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Down syndrome (trisomy 21) patients show an increased risk of thyroid disorders, particularly hypothyroidism. Early clinical and endocrinological follow-up is crucial for timely diagnosis and management in these children.

Area of Science:

  • Endocrinology
  • Genetics
  • Pediatrics

Context:

  • Down syndrome (trisomy 21) is a genetic condition associated with various health complications.
  • Thyroid dysfunction is a known concern in the Down syndrome population.
  • Evaluating thyroid function is essential for comprehensive patient care.

Purpose:

  • To assess thyroid function in patients with Down syndrome.
  • To investigate the prevalence of thyroid disorders in trisomy 21.
  • To determine the association between Down syndrome and thyroid dysfunction.

Summary:

  • The study evaluated 45 Down syndrome patients for thyroid function.
  • One case of subclinical hypothyroidism was diagnosed in 28 subjects.
  • Transient neonatal hyperthyrotropinemia was observed in one infant; others were euthyroid.

Related Experiment Videos

  • Altered thyroid functions were noted in children with trisomy 21 and heart anomalies.

    • Impact:

    • Highlights the increased risk of thyroid disorders in Down syndrome.
    • Recommends regular clinical and endocrinological monitoring for early detection.
    • Emphasizes the importance of managing thyroid dysfunction to improve outcomes in trisomy 21.