Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nosocomial infection with vancomycin-dependent enterococci.

Paul A Tambyah1, John A Marx, Dennis G Maki

  • 1University of Wisconsin Medical School, Madison, USA. mdcpat@nus.edu.sg

Emerging Infectious Diseases
|August 25, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vulnerabilities in pandemic responses.

Public health·2026
Same author

Ivermectin for Critically and Noncritically Ill Hospitalized Patients With COVID-19: Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community-Acquired Pneumonia (REMAP-CAP).

Critical care medicine·2026
Same author

Clinical challenges to improve antimicrobial stewardship in outpatient care.

The American journal of medicine·2025
Same author

In critically ill patients, preoxygenation with NIPPV or HFNC vs. face mask reduces hypoxemia during intubation.

Annals of internal medicine·2025
Same author

Link between compliance with, or implementation of, the SEP-1 sepsis bundle and mortality is mixed (low-level evidence).

Annals of internal medicine·2025
Same author

ACE2 and TMPRSS2 gene expression is reduced acutely in SARS-CoV-2 patients but returns to normal with recovery.

Scientific reports·2025
Same journal

Detection of and Early Genomic Insights into Chikungunya Virus, Bolivia, 2025.

Emerging infectious diseases·2026
Same journal

Household Transmission of Enterovirus D68, Washington and Oregon, United States, 2022-2024.

Emerging infectious diseases·2026
Same journal

New World Ocular Dirofilariasis Caused by Dirofilaria repens Infection, United States.

Emerging infectious diseases·2026
Same journal

Angiostrongylus cantonensis Rat Lungworm Detected in Rats, Madagascar, 2022-2023.

Emerging infectious diseases·2026
Same journal

Human Pulmonary Dirofilariasis,
North Queensland, Australia, 2023<sup>1</sup>.

Emerging infectious diseases·2026
Same journal

Trends in Congenital Syphilis Cases by Maternal Country of Birth, Spain, 2016-2024.

Emerging infectious diseases·2026
See all related articles

Prolonged vancomycin exposure may lead to vancomycin-dependent enterococci infections. This study observed unique strains in patients with extensive vancomycin and cephalosporin use, suggesting a link between antibiotic pressure and resistance evolution.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Antimicrobial Resistance

Background:

  • Vancomycin-resistant enterococci (VRE) are a significant nosocomial pathogen.
  • The evolution of antimicrobial resistance, including vancomycin dependence, is a growing concern.
  • Enterococcal infections pose challenges in healthcare settings.

Purpose of the Study:

  • To report on patients infected with unique strains of vancomycin-dependent enterococci.
  • To investigate the potential role of prolonged vancomycin exposure in the development of vancomycin dependence.
  • To compare antimicrobial exposure in patients with vancomycin-dependent enterococci versus control groups.

Main Methods:

  • Case series reporting on three patients with vancomycin-dependent enterococci.

Related Experiment Videos

  • Comparison of antimicrobial exposure (vancomycin, third-generation cephalosporins) between cases and two control groups (VRE-infected and non-enterococcal infection patients).
  • Genetic analysis of enterococcal strains.

    • Main Results:

    • Three patients were infected with unique vancomycin-dependent enterococci strains.
    • Two patients were initially infected with genetically identical vancomycin-resistant enterococci strains.
    • Patients with vancomycin-dependent enterococci showed significantly greater exposure to vancomycin and third-generation cephalosporins compared to controls.

    Conclusions:

    • Antimicrobial pressure, particularly from vancomycin, may drive nosocomial colonization by VRE.
    • Prolonged vancomycin exposure might facilitate the emergence of vancomycin dependence from vancomycin resistance.
    • Understanding these evolutionary pathways is crucial for infection control and treatment strategies.